Diterpene Synthases and Their Responsible Cyclic Natural Products
نویسندگان
چکیده
منابع مشابه
Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis
Arabidopsis thaliana maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which have been associated with direct and indirect defensive activities in flowers and leaves. In comparison, the structural diversity and function of terpenes in Arabidopsis roots has remained largely unexplored despite a ...
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The diversity of terpenoid compounds produced by plants plays an important role in mediating various plant-herbivore, plant-pollinator, and plant-pathogen interactions. This diversity has resulted from gene duplication and neofunctionalization of the enzymes that synthesize and subsequently modify terpenes. Two diterpene synthases in Norway spruce (Picea abies), isopimaradiene synthase and levo...
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Plants produce an immense diversity of natural products (i.e. secondary or specialized metabolites) that offer a rich source of known and potentially new pharmaceuticals and other desirable bioproducts. The Traditional Chinese Medicinal plant Isodon rubescens (Lamiaceae) contains an array of bioactive labdane-related diterpenoid natural products. Of these, the ent-kauranoid oridonin is the most...
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Diterpenoid natural products cover a vast chemical diversity and include many medicinally and industrially relevant compounds. All diterpenoids derive from a common substrate, (E,E,E)-geranylgeranyl diphosphate, which is cyclized into one of many scaffolds by a diterpene synthase (DTS). While diterpene biosynthesis has been extensively studied in plants and fungi, bacteria are now recognized fo...
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Terpene synthases/cyclases yield core structures of some of the most valuable bioactive molecules, such as artemisinin and paclitaxel. A detailed understanding of structure–function relationship of terpene synthases/ cyclases delineates the evolutionary relationship between different enzymes and molecular basis of their strategies to direct and manipulate carbocation intermdiates throughout the...
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ژورنال
عنوان ژورنال: Natural Products and Bioprospecting
سال: 2014
ISSN: 2192-2195,2192-2209
DOI: 10.1007/s13659-014-0012-8